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The FY20 Defense Appropriations Act provides funding to the Department of Defense Peer Reviewed Medical Research Program (PRMRP) to support to support medical research projects of clear scientific merit and direct relevance to military health. As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).
The FY20 PRMRP Program Announcements and General Application Instructions for the following award mechanisms are posted on the Grants.gov website.
The vision and mission of the PRMRP is improve the health, care, and well-being of all military Service members, Veterans, and beneficiaries by encouraging, identifying, selecting, and managing medical research projects of clear scientific merit and direct relevance to military health.
Congressionally Directed Topic Areas: All applications submitted to the PRMRP must address at least one of the FY20 PRMRP Congressionally directed topic areas. The FY20 PRMRP Topic Areas are as follows:
· Arthritis
· Burn Pit Exposure
· Chronic Migraine and Post-Traumatic Headache
· Congenital Heart Disease
· Constrictive Bronchiolitis
· Diabetes
· Dystonia
· Eating Disorders
· Emerging Viral Diseases
· Endometriosis
· Epidermolysis Bullosa
· Familial Hypercholesterolemia
· Fibrous Dysplasia
· Focal Segmental Glomerulosclerosis
· Food Allergies
· Fragile X
· Frontotemporal Degeneration
· Guillain-Barré Syndromemorrhage Control
· Hepatitis B
· Hydrocephalus
· Immunomonitoring of Intestinal Transplants
· Inflammatory Bowel Diseases
· Interstitial Cystitis
· Metals Toxicology
· Mitochondrial Disease
· Musculoskeletal Health
· Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
· Myotonic Dystrophy
· Nutrition Optimization
· Pancreatitis
· Pathogen-Inactivated Blood Products
· Plant-Based Vaccines
· Polycystic Kidney Disease
· Pressure Ulcers
· Pulmonary Fibrosis
· Resilience Training
· Respiratory Health
· Rheumatoid Arthritis
· Sleep Disorders and Restriction
· Spinal Muscular Atrophy
· Sustained Release Drug Delivery
· Vascular Malformations
· Women’s Heart Disease
https://cdmrp.army.mil/funding/prmrp
Discovery Award – Letter of Intent due April 16, 2020
Postdoctoral fellow or clinical fellow (or equivalent) and above
· Maximum of $200,000 for direct costs (plus indirect costs)
· Maximum period of performance is 2 years
Focused Program Award – Preproposal due April 23, 2020
Full Professor level or above (or equivalent)
· Maximum of $7.2 million for direct costs (plus indirect costs)
· Maximum period of performance is 4 years
Investigator-Initiated Research Award – Preproposal due April 23, 2020
Assistant Professor level or above (or equivalent)
· Maximum of $1.6 million for direct costs (plus indirect costs)
· Maximum of $2 million for direct costs (plus indirect costs) for applications including a Partnering PI Option
Technology/ Therapeutic Development Award – Preproposal due April 23, 2020
· Maximum of $4 million for direct costs (plus indirect costs
A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final Program Announcements and General Application Instructions available for electronic downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.
For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the PRMRP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).
Point of Contact:
The FY20 Defense Appropriation provides $15 million (M) to the Department of Defense Autism Research Program (ARP) to provide support for research of exceptional scientific merit and innovation with high impact that focuses on autism spectrum disorders (ASD). As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate, manages the Defense Health Program’s Research, Development, Test, and Evaluation (RDT&E) appropriation. The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).
FY20 ARP Program Announcements and General Application Instructions for the following award mechanisms are posted on the Grants.gov website.
https://cdmrp.army.mil/funding/arp
Clinical Trial Award – preapplication due April 15, 2020
Investigators at or above the level of Assistant Professor (or equivalent), or
Early-Career Investigator Partnering Principal Investigator (PI) Option: Investigators at or above the level of Assistant Professor (or equivalent) may collaborate on a single application with a young investigator (at the level of postdoctoral fellow up to early-career independent faculty) who meets the following criteria at the application submission deadline date:
Supports research with the potential to have a major impact on the treatment and/or management of ASD.
Applications in the following areas are strongly encouraged:
Preliminary data relevant to the proposed clinical trial are required.
Pre-application is required; application submission is by invitation only.
Early-Career Investigator Partnering PI Option supports the development of young investigators pursuing or wishing to pursue a career in ASD clinical trial research.
The maximum allowable funding for the entire period of performance is $2,000,000 in direct costs (plus indirect costs).
Maximum period of performance is 4 years.
Early-Career Investigator Partnering PI Option:
The maximum allowable funding for the entire period of performance is $2,300,000 for direct costs (plus indirect costs).
Clinical Translational Research Award – preapplication due April 15, 2020
Investigators at or above the level of Assistant Professor (or equivalent)
Idea Development Award – preapplication due April 15, 2020
Multiple PI Option: Up to two investigators may collaborate on a single application, each of whom will be recognized as a PI and receive a separate award.
For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the ARP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).
The FY20 Defense Appropriations Act provides funding to the Department of Defense Epilepsy Research Program (ERP) to understand the causative links between traumatic brain injury (TBI) and epilepsy so that post-traumatic epilepsy (PTE) will be both preventable and treatable. As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).
The ERP is providing the information in this pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY20 funding opportunity. This pre-announcement should not be construed as an obligation by the Government. The FY20 ERP Program Announcements and General Application Instructions for the following award mechanisms will be posted on the Grants.gov website. Pre-application and application deadlines will be available when the Program Announcements are released.
Applications submitted to the FY20 ERP should address one or more of the following Focus Areas. An application that proposes research outside of the FY20 Focus Areas is acceptable, as long as the applicant provides a strong rationale. The Focus Areas will be mechanism-specific.
https://cdmrp.army.mil/pubs/press/2020/20erppreann
Idea Development Award
Level I: Funding Level I is intended to support early-career investigators ranging from the post-doctoral level (e.g. research associate, fellows, residents or equivalent) to within 3 years of their first independent faculty position. (mentor required)
Level II: The Principal Investigator (PI) must be an independent investigator at or above the level of Assistant Professor (or equivalent)
Intent: To support novel, innovative research to understand the magnitude and underlying mechanisms of PTE.
The following Focus Areas are open to both Levels I and II:
Preliminary data, while not required, are encouraged for both levels.
Clinical pharmacologic trials are specifically discouraged.
Level I:
· Maximum funding of $300,000 for direct costs (plus indirect costs)
· Maximum period of performance is 3 years
· Indirect costs may be proposed in accordance with the institution’s rate agreement
Level II:
· Maximum funding of $500,000 for direct costs (plus indirect costs)
Quality of Life Award
Level II: The PI must be an independent investigator at or above the level of Assistant Professor (or equivalent).
Intent: To support innovative research that improves the quality of life and care for individuals living with the common symptoms of PTE and/or their families and care providers, as related to the ERP’s mission.
Research Partnership Award
The PI must be an independent investigator at or above the level of Assistant Professor (or equivalent).
Intent: To create an avenue for collaborative research partnerships between/among investigators to address a research problem or question in a manner that would be unachievable through separate efforts.
· Level I is intended to support preclinical or pre-validation research.
· Level II is intended to support research requiring access to a patient cohort for a prospective study.
Applications must include clearly stated plans for interactions between/among the partners. The plans must include communication, coordination of research progress and results, and data sharing between all investigators and organizations participating in the project.
· Markers and Mechanisms
· Epidemiology
· Longitudinal Studies
Preliminary data are required.
Clinical pharmacologic trials are specifically discouraged
· Maximum funding of $1,300,000 in total costs
· Maximum funding of $3,100,000 in total costs
A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final Program Announcements and General Application Instructions that will be available for electronic downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.
Submission deadlines are not available until the Program Announcements are released. For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the ERP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).
CDMRP Public Affairs 301-619-9783 usarmy.detrick.medcom-cdmrp.mbx.cdmrp-public-affairs@mail.mil
The FY20 Defense Appropriations Act provides funding to the Department of Defense Multiple Sclerosis Research Program (MSRP) to support innovative and impactful research that addresses fundamental issues and gaps in Multiple Sclerosis (MS). As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).
The MSRP is providing the information in this pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY20 funding opportunity. This pre-announcement should not be construed as an obligation by the Government. The FY20 MSRP Program Announcements and General Application Instructions for the following award mechanisms will be posted on the Grants.gov website. Pre-application and application deadlines will be available when the Program Announcements are released.
https://cdmrp.army.mil/pubs/press/2020/20msrppreann
Applications submitted to the FY20 MSRP must address at least one of the Focus Areas relevant to the award mechanism as described below.
Clinical Trial Award (NEW!!!)
· Pre-application submission is required; application submission is by invitation only.
· Funds Phase I or II clinical trials relevant to MS; combinations of phases are permitted.
· Funding must support a clinical trial and may not be used for preclinical studies.
· Scientific rationale and preliminary data are required.
· Must address at least one of the following Focus Areas:
o Promoting Repair, Neuroprotection, and Remyelination in MS
Treatment of MS Symptoms
· Maximum funding of $1,500,000 for direct costs (plus indirect costs).
· Maximum period of performance is 4 years.
Exploration -Hypothesis Development Award
Established Investigators:Independent investigators at or above the level of Assistant Professor (or equivalent) or
New Investigators:
· Independent investigators no more than 3 years from the start of their faculty position
· Must not have a Research Project Grant (R01) or similar non-mentored award
UPDATED!!!
· Supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the MS research field.
· Preliminary data not required.
· Clinical trials not allowed.
· New Investigator Option supports applicants early in their faculty appointments.
o Promoting Central Nervous System Regenerative Potential in Demyelinating Conditions
o Correlates of Disease Activity and Progression in MS
o Biology and Measurement of MS Symptoms
Identify the Role of Factors in MS Etiology, Prodome, Onset, and Evolution, Including Repair Processes (NEW!!!)
· Maximum funding of $150,000 for direct costs (plus indirect costs).
· Maximum period of performance is 2 years.
Investigator-Initiated Research Award
Independent investigators at or above the level of Assistant Professor (or equivalent)
· Supports highly rigorous, high-impact research with the potential to make an important contribution to MS research and/or patient care.
· Preliminary data required.
· Maximum funding of $600,000 for direct costs (plus indirect costs).
· Maximum period of performance is 3 years.
Submission deadlines are not available until the Program Announcements are released. For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the MSRP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).
The FY20 Defense Appropriations Act provides funding to the Department of Defense Lung Cancer Research Program (LCRP) to support innovative, high-impact lung cancer research. As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).
The LCRP is providing the information in this pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY20 funding opportunities. This pre-announcement should not be construed as an obligation by the Government. The FY20 LCRP Program Announcements and General Application Instructions for the following award mechanisms will be posted on the Grants.gov website. Pre-application and application deadlines will be available when the Program Announcements are released.
Applications submitted to the FY20 LCRP must address one or more of the following Areas of Emphasis:
Relevance to Military Health: The LCRP seeks to support research that is relevant to the healthcare needs of military Service members, Veterans, and their families. Relevance to military health will be considered in determining relevance to the mission of the DHP and FY20 LCRP during programmatic review. Investigators are strongly encouraged to consider the following characteristics as examples of how a project may demonstrate relevance to military health:
https://cdmrp.army.mil/pubs/press/2020/20lcrppreann
Concept Award
Investigators at all academic levels
· Supports highly innovative, untested, potentially groundbreaking concepts in lung cancer.
· Emphasis on innovation.
· Preliminary data discouraged.
· Relevance to military health strongly encouraged.
· Maximum funding of $100,000 in direct costs (plus indirect costs).
· Period of performance should not exceed 1 year.
Career Development Award
· Principal Investigator: Independent investigators at the level of Assistant Professor, Instructor, or equivalent; must be within 5 years of first faculty appointment
· Mentor: At or above the level of Associate Professor (or equivalent); have a proven publication and funding record in lung cancer research
· Supports early-career, independent researchers to conduct research under mentorship of an experienced lung cancer researcher.
· Maximum funding of $250,000 in direct costs (plus indirect costs).
· Period of performance should not exceed 2 years.
Established Investigators: Independent investigators at or above the level of Assistant Professor (or equivalent); or
New Investigators: Investigators that meet the following criteria by the application submission deadline date:
· Have not previously received a LCRP Idea Development Award or Early Investigator Synergistic Idea Award
· Are within 10 years of first faculty appointment (or equivalent)
· Supports new ideas in the early stages of development representing innovative, high-risk/high-gain research.
· Emphasis on innovation and impact.
· New Investigator category supports applicants early in their faculty appointments or in the process of developing independent research careers.
· Maximum funding of $350,000 in direct costs (plus indirect costs).
Investigator-Initiated Translational Research Award
· Supports translational research that will develop promising ideas in lung cancer into clinical applications. Translational research may be defined as an integration of basic science and clinical observations.
· This mechanism is intended to fund a broad range of translational studies including, but not limited to, the following:
o Studies advancing/translating in vitro and/or animal studies to applications with human samples/cohorts
o Late-stage preclinical work leading to/preparing for a clinical trial, e.g., Investigational New Drug submission
o Correlative studies that are associated with an ongoing or completed clinical trial and projects that develop endpoints for clinical trials
· Maximum funding of $400,000 in direct costs (plus indirect costs).
Clinical Translational Research Partnership Award
· Supports translational studies that include a clinical trial.
· This mechanism is intended to fund partnerships between clinicians and laboratory scientists that accelerate ideas in lung cancer into clinical applications.
o One partner is strongly encouraged to be from either a military treatment facility or a Department of Veterans Affairs medical center.
· Non-traditional partnerships are encouraged
· Patient research advocate involvement encouraged.
· Biostatistician involvement encouraged.
· Maximum combined funding of $1,200,000 for direct costs (plus indirect costs).
A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.orgprior to the pre-application deadline. All applications must conform to the final Program Announcements and General Application Instructions that will be available for electronic downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.
Submission deadlines are not available until the Program Announcements are released. For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the LCRP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).
The FY20 Defense Appropriations Act provides funding to the Department of Defense Tick-Borne Disease Research Program (TBDRP) to support innovative, high-impact tick-borne disease research. As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).
The TBDRP is providing the information in this pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY20 funding opportunity. This pre-announcement should not be construed as an obligation by the Government. The FY20 TBDRP Program Announcements and General Application Instructions for the following award mechanisms will be posted on the Grants.gov website. Pre-application and application deadlines will be available when the Program Announcements are released.
Applications submitted to the FY20 TBDRP must address one or more of the following Focus Areas:
* Diagnosis:
o Sensitive and specific direct detection diagnostic assay for Borrelia and/or other TBD pathogens. Assay should ultimately be amenable for implementation in a typical clinical setting, cost-effective, and rapid (diagnosis in < 24 hours).
o Diagnostic biomarker panel for Lyme disease and other TBDs that distinguishes TBD infection from other febrile illnesses.
o Approaches for Lyme disease or other TBD diagnosis capable of distinguishing active infection and previous exposure, and/or monitoring response to treatment.
o Innovative and new approaches that provide diagnosis for a single or multiple TBD infections from a single sample.
* Treatment:
o Therapeutic strategies for treating acute and persistent TBDs. Novel therapeutics and/or non-antibiotic modalities for treating TBDs are encouraged.
o In vitro interrogation of potential treatments designed to mitigate development of long-term sequelae following infection with bacterial, parasitic, or viral tick-borne (TB) agents.
* Immunomodulatory approaches to treat the inflammatory response to infection.
* Prevention:
o Drugs, antibodies, or other novel approaches that can be administered and/or utilized prophylactically to prevent human TBD infection.
o Safe and effective human vaccines for TBDs.
o Identification, validation, and/or improvement of tick- or reservoir-targeted prevention and control interventions.
o Understanding the ecology of understudied TBD vectors and reservoirs with emphasis on how it relates to human risk.
* Pathogenesis:
o Pathogenesis of persistent clinical manifestations associated with Lyme disease.
o Immune evasion and/or tolerance of TB pathogens (Lyme and/or other TBDs).
o Effects of tick sialome on human infection, immune response, disease progression, and pathogen dissemination.
o TB infections and co-infections (simultaneous or sequential) and their effects on human disease severity, the local and systemic immune response, and/or pathogen synergy and competition.
o Red meat allergy (allergic response to alpha-gal).
https://cdmrp.army.mil/pubs/press/2020/20tbdrppreann
Principal Investigator (PI):
Investigators within 10 years of completing terminal degree (excluding time in medical residency or on family medical leave) at the time of application submission, working to become independent investigators who exhibit a strong desire to pursue careers in tick-borne disease research; time spent as a postdoctoral fellow is not excluded
Mentor: Independent investigators at or above the level of Associate Professor (or equivalent); must be an experienced tick-borne diseases researcher as demonstrated by a recent (last 5 years) history of funding and publications in tick-borne diseases research, specifically in the field (pathogen and associated methods) of the proposed studies.
The PI and Mentor may be at different organizations.
* To fund early-career investigators to conduct impactful research under the mentorship of an experienced tick-borne disease researcher.
* Career Development Plan is required for invited application submission. Plan should be prepared with appropriate guidance from the Mentor, should clearly articulate a strategy for acquiring the necessary skills, competence, and expertise to establish a career at the forefront of tick-borne disease research, and should outline how the PI will gain experience in tick-borne disease research. PI's institution must demonstrate a commitment to the PI through a minimum of 75% protected research time for tick-borne disease research. The application must include clearly stated plans for interactions and communication coordination between the PI and Mentor.
* Mentorship is required
* Preliminary data is encouraged, but not required.
* Clinical trials are not allowed; human studies/clinical research are permitted.
* Preproposal is required; application submission is by invitation only.
* Maximum funding of $300K for direct costs (plus indirect costs)
* Maximum period of performance is 3 years
* To fund research that could lead to impactful discoveries or major advancements that will accelerate progress in improving outcomes for individuals affected by Lyme diseases and/or other tick-borne illnesses
* Research should be conceptually innovative, exhibit high levels of creativity, or challenge existing research paradigms.
* Applications must describe the short- and long-term impact of the proposed research, as well as the public health burden of the diseases being addressed.
* Maximum funding of $600K for direct costs (plus indirect costs)
The FY20 Defense Appropriations Act providing funding to the Department of Defense ALSRP to support innovative and impactful research to develop new treatments for ALS. As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).
FY20 ALSRP Program Announcements and General Application Instructions for the following award mechanisms are posted on the Grants.gov website.
https://cdmrp.army.mil/funding/alsrp
Therapeutic Development Award - Pre-Application March 27, 2020
Independent investigators at all academic levels (or equivalent)
· Pre-application is required; full application submission is by invitation only.
· Supports preclinical secondary validation and IND-enabling studies of therapeutics for ALS.
· Preliminary data is required, including efficacy in at least one ALS-relevant model system with a lead molecule/class of compounds.
· Biomarker development and/or characterization (if not already validated), in parallel to the main therapeutic effort, is a critical component of the TDA proposal.
· Maximum funding of $1,000,000 for direct costs plus indirect costs
Therapeutic Idea Award - Pre-Application March 27, 2020
· Supports hypothesis-driven preclinical therapeutic development.
· Preliminary data are not required.
· Projects focusing primarily on investigating ALS pathophysiology are outside the scope of this award mechanism.
· Early Career Investigators are encouraged to apply.
· Therapeutic Relevant Biomarker Option: Applications which include the development of biomarkers in parallel with the main therapeutic advancement effort, and that meet the criteria outlined in the Funding Opportunity Announcement, will qualify for a higher level of funding.
· Maximum funding of $500,000 for direct costs plus indirect costs
· Maximum funding of $600,000 for direct costs plus indirect costs if applying for the Therapeutic Relevant Biomarker Option
New for FY20! Clinical Development Award - Pre-Application March 27, 2020
· Supports leveraging of human-based ALS resources through correlative clinical research.
· Early Career Investigators and/or Early Career Physician Scientists are encouraged to apply.
· Types of efforts that will be supported include:
o Using human subject-based resources to better define subtypes, predict therapeutic response, or assess prognosis
o Correlating clinical trial-related biosamples, imaging, or epidemiological data with clinical outcomes
o Adding a secondary aim/goal to an anticipated/ongoing clinical trial, not otherwise supported by the trial
o Studies to evaluate optimizing components of current ALS clinical care
· Maximum funding of $300,000 for direct costs plus indirect costs
For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the ALSRP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).
The FY20 Defense Appropriation Act provides $15 million to the Department of Defense Orthotics and Prosthetics Outcomes Research Program (OPORP) to support research on outcomes-based best practices through analysis of the merits of prosthetic and orthotic device options currently available, not on the development of new or the improvement of existing technology. As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The managing agent for the anticipated Program Announcement/Funding Opportunity is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).
The OPORP is providing the information in this pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY20 funding opportunity. This pre-announcement should not be construed as an obligation by the Government. The FY20 OPORP Program Announcements and General Application Instructions for the following award mechanisms will be posted on the Grants.gov website. Pre-application and application deadlines will be available when the Program Announcements are released.
OPORP supports research that evaluates orthoses and/or prostheses using patient-centric outcomes relevant to Service members and Veterans with limb loss and/or limb impairment. The intent of this research is to generate clinically useful evidence that will enhance and optimize patient outcomes. Applications submitted to the FY20 OPORP must address at least one of the following Focus Areas:
https://cdmrp.army.mil/pubs/press/2020/20oporppreann
Clinical Research Award
Independent investigators at all academic levels (or equivalent).
Funding Level 1
Funding Level 2
Clinical Trial Award
Submission deadlines are not available until the Program Announcements are released. For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the OPORP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).
The FY20 Defense Appropriation Act provides $3 million (M) to the Department of Defense Bone Marrow Failure Research Program (BMFRP) to provide support for research of exceptional scientific merit and innovation with high impact that focuses on BMF diseases. As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate, manages the Defense Health Program’s Research, Development, Test, and Evaluation (RDT&E) appropriation. The managing agent for the anticipated Program Announcement/Funding Opportunity is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).
The BMFRP is providing the information in this pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY20 funding opportunity. This pre-announcement should not be construed as an obligation by the Government. The FY20 BMFRP Program Announcement and General Application Instructions for the following award mechanism will be posted on the Grants.gov website. Pre-application and application deadlines will be available when the Program Announcement is released.
https://cdmrp.army.mil/pubs/press/2020/20bmfrppreann
Established Investigators: Independent investigators at or above the level of Assistant Professor (or equivalent) and 10 years or more from first faculty appointment (or equivalent) or
Early Career Investigators: Independent investigators at the level of Assistant Professor (or equivalent) and less than 10 years from first faculty appointment (or equivalent).
A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final Program Announcement and General Application Instructions that will be available for electronic downloading from the Grants.gov website. The application package containing the required forms for the award mechanism will also be found on Grants.gov. A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.
Submission deadlines are not available until the Program Announcements are released. For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the BMFRP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).
The Fiscal Year 2020 Department of Defense Appropriations Act provides research funding for the following peer reviewed programs managed by the Department of Defense office of Congressionally Directed Medical Research Programs (CDMRP):
https://cdmrp.army.mil/pubs/press/2020/funding_press_release20
Pre-announcements and comprehensive Program Announcements will be forthcoming. The pre-announcements will provide a general overview of the anticipated funding mechanisms. The Program Announcements will include detailed descriptions of funding mechanisms, evaluation criteria, submission requirements, and deadlines. Each Program Announcement may be downloaded from the Grants.gov website http://www.grants.gov, or the CDMRP website https://cdmrp.army.mil upon its release. For email notification when pre-announcements and Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the CDMRP, our research programs, previous awardees, as well as research highlights and videos, please visit the website at https://cdmrp.army.mil.
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